The Journal of General Physiology Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel
نویسندگان
چکیده
In the article, the reference Perez-Cornejo and Arreola (2004. Regulation of Ca2+-activated chloride channels by cAMP and CFTR in parotid acinar cells. Biochem. Biophys. Res. Commun. 316:612–617. http://dx.doi.org/10.1016/j.bbrc .2004.02.097) should not have been cited. The reference that should have been cited instead is Perez-Cornejo, P., J.A. De Santiago, and J. Arreola. 2004. Permeant anions control gating calcium-activated chloride channels. J. Membr. Biol. 198:125–133. http://dx.doi.org/10.1007/s00232-004-0659-x.
منابع مشابه
Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel
At least two members of the TMEM16/anoctamin family, TMEM16A (also known as anoctamin1) and TMEM16B (also known as anoctamin2), encode Ca(2+)-activated Cl(-) channels (CaCCs), which are found in various cell types and mediate numerous physiological functions. Here, we used whole-cell and excised inside-out patch-clamp to investigate the relationship between anion permeation and gating, two proc...
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Ca(2+)-activated Cl(-) channels (CaCCs) are involved in several physiological processes. Recently, TMEM16A/anoctamin1 and TMEM16B/anoctamin2 have been shown to function as CaCCs, but very little information is available on the structure-function relations of these channels. TMEM16B is expressed in the cilia of olfactory sensory neurons, in microvilli of vomeronasal sensory neurons, and in the s...
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TMEM16A and TMEM16B encode for Ca2+-activated Cl- channels (CaCC) and are expressed in many cell types and play a relevant role in many physiological processes. Here, I performed a site-directed mutagenesis study to understand the molecular mechanisms of ion permeation of TMEM16B. I mutated two positive charged residues R573 and K540, respectively located at the entrance and inside the putative...
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